Whiskies of the World takes place in several major cities: San Francisco, San Jose, Austin, Houston, Dallas and Atlanta. All of these have international airports and extensive highway systems. Just choose the one closest to you (or the city you want to drink whisky in most) and make your travel plans accordingly.
Depending on which city you choose, there are special deals at nearby hotels. Check the festival’s website under your city’s respective events page, and you can get information about hotels there.
Drinking yourself into oblivion is always possible when there’s unlimited samples, so respect your limits and the other guests in attendance while you’re here. Drink plenty of water, have a designated driver with you or take a rideshare in case you go overboard.